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KMID : 0812020110170040395
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Korean Journal of Neurogastroenterology and Motility
2011 Volume.17 No. 4 p.395 ~ p.401
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Mosapride Accelerates the Delayed Gastric Emptying of High-Viscosity Liquids: A Crossover Study Using Continuous Real-Time 13C Breath Test (BreathID System)
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Sakamoto Yasunari
Sekino Yusuke
Yamada Eiji
Ohkubo Hidenori
Higurashi Takuma
Sakai Eiji
Iida Hiroshi
Hosono Kunihiro
Endo Hiroki
Nonaka Takashi
Ikeda Tamon
Fujita Koji
Yoneda Masato
Koide Tomoko
Takahashi Hirokazu
Goto Ayumu
Abe Yasunobu
Gotoh Eiji
Maeda Shin
Nakajima Atsushi
Inamori Masahiko
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Abstract
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Background/Aims: The administration of liquid nutrients to patients is often accompanied by complications such as gastroesophageal reflux. To prevent gastroesophageal reflux, high-viscosity liquid meals are used widely, however, it still remains controversial whether high-viscosity liquid meals have any effect on the rate of gastric emptying. The present study was conducted with the aim of determining whether high-viscosity liquid meals had any effect on the rate of gastric emptying and mosapride might accelerate the rate of gastric emptying of high-viscosity liquid meals.
Methods: Six healthy male volunteers underwent 3 tests at intervals of ＞ 1 week. After fasting for ＞ 8 hours, each subject received one of three test meals (liquid meal only, high-viscosity liquid meal [liquid meal plus pectin] only, or high-viscosity liquid meal 30 minutes after intake of mosapride). A 13C-acetic acid breath test was performed, which monitored the rate of gastric emptying for 4 hours. Using the Oridion Research Software (b version), breath test parameters were calculated. The study parameters were examined for all the 3 test conditions and compared using the Freidman test.
Results: Gastric emptying was significantly delayed following intake of a high-viscosity liquid meal alone as compared with a liquid meal alone; however, intake of mosapride prior to a high-viscosity liquid meal was associated with a significantly accelerated rate of gastric emptying as compared with a high-viscosity liquid meal alone.
Conclusions: This study showed that high-viscosity liquid meals delayed gastric emptying: however, mosapride recovered the delayed rate of gastric emptying by high-viscosity liquid meals.
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KEYWORD
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Breath test, Gastric emptying, Mosapride, Pectin
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